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Dimensionality reduction methodssuch as principal component analysis (PCA), t-distributed stochastic neighbor embedding (t-SNE), Uniform Manifold Approximation and Projection (UMAP), singular value decomposition (SVD), or non-negative matrix factorization (NMF) can be applied to reduce the dimension of the similarity matrix along with the statistical tests and feature rankings to represent the data with minimum information loss (Meng et al., 2016

In some embodiments, the otic formulation or composition comprises about 4% by weight of the silicon dioxide

doi: 10.2337/DB12-0432/-/DC1 45 MartinsCPNewLAOConnorECPreviteDMCargillKRTseILet al

Vero cell viability was assessed at 24 h by measuring ATP content using Cell Titer Glo Assay as described 83