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10.1016/j.bbmt.2016.07.013 34 PhilippeM.NeelyM.RushingT.BertrandY.BleyzacN.GoutelleS

doi:10.5534/wjmh.200112 Vance ML, Mauras N

The modified Kligmans formulacombining hydroquinone, tretinoin, and a corticosteroidhas been a dermatology compounding staple for decades

Across the cagrilintide clinical program, the dominant tolerability issues have been gastrointestinal: nausea, reduced appetite, constipation, and, less commonly, vomiting a profile shared with pramlintide and with GLP-1 agonists, and mechanistically expected from a compound that slows the stomach and engages the area postrema