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This confirms that retatrutide's weight-loss trajectory had not plateaued at 80 weeks, unlike semaglutide and tirzepatide trials where the curve flattens between weeks 60 and 72
10.1210/en.2016-1839 28
The 28% average body weight reduction observed in retatrutides Phase 3 programme, alongside an 82.4% reduction in liver fat in MASLD participants, positions it as the most potent incretin-based compound currently in late-stage development [2][4]
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