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Como vrios subtipos de receptores de melanocortina podem ser expressos em diferentes tecidos e sistemas de modelos experimentais, estudos mecansticos frequentemente incorporam mtodos de atribuio de subtipos (por exemplo, antagonistas seletivos, estratgias de silenciamento/desativao de receptores ou controles de expresso de receptores) para associar os resultados bioqumicos observados a populaes especficas de receptores

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