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Considering the preservation of lean mass and improved metabolic profiles, exploring biomarkers related to muscle protein synthesis during de-escalation might be a valuable avenue for future research.

A GLP-1-only plan targets one pathway related to appetite and digestion, while GIP + GLP-1 targets two pathways that may enhance metabolic response and insulin sensitivity for some people

Ultimately, elucidating the mechanisms that govern transitions between protective and pathological states will be critical to refine classification systems and to guide therapeutic strategies targeting astrocyte reactivity

Whilst there is no formal contraindication to using these medications in ulcerative colitis, important considerations exist