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A synthetic pentadecapeptide (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val), BPC-157 was first isolated from human gastric juice by Predrag Sikiric and Sven Seiwerth at the University of Zagreb School of Medicine in the early 1990s.3 Sikirics laboratory has since published more than 200 studies on the compoundan extraordinary body of work that has attracted both admiration for its breadth and criticism for originating almost entirely from a single research group

Metabolic AMPK/SIRT1 Activator Dihydroberberine Dihydroberberine is a highly bioavailable form of berberine that supports healthy metabolism, improves insulin sensitivity, and promotes fat burning with fewer side effects

Third, independent replication outside the original group has been limited , although a 2025 paper in Biogerontology by Al-Dulaimi and colleagues represents a recent independent confirmation of the in vitro telomere effect