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3.3 Cellular uptake An additional key determinant of photochemical ICD by light activated lipid nanoformulations that we previously identified is a high efficiency of intracellular uptake [9]

Because the milligram amount is fixed, a lighter body gets more drug exposure per pound: roughly 22% more at 70 kg and about a third less at 120 kg, compared with a 90 kg reference. The dose still comes from response and tolerability, but a lighter person is running a hotter exposure at the same number on the vial

In the real world, the most immediate risk is often not the molecule it is the supply chain