This review summarizes the molecular characteristics and antioxidant functions of GPX4, evaluates experimental evidence linking GPX4 and ferroptosis in OA, outlines upstream and downstream molecular mechanisms regulating GPX4, and summarizes therapeutic strategies targeting GPX4, including pharmacological, gene, and combination therapies
To determine the role of HOXA2 in SIRT1 expression, a HOXA2 overexpression plasmid was constructed and used to transfect HK-2 cells
The experimental animal should be gently removed from the breeding cage, ensuring it faces away from the experimenter, then quickly placed in the central area of the experimental box before the experimenter promptly exits
B12 addition does not alter GS-441524 concentration, dosing calculation, or mechanism of action