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In this section, we discuss key hurdles and future directions: standardization and quality control of natural products, mechanistic complexity and polypharmacology, clinical translation and integration with current therapies, and others

Transplantation studies demonstrate that BL treatment significantly reduces serum IFN- levels while promoting Treg expansion (Pareek et al., 2022), suggesting a dual mechanism that suppresses both neurotoxic microglial activation and effector T cell responses, while enhancing Treg-mediated protection of DA neurons

It is specifically characterized by inflammation, demyelination, and neuronal loss and manifests with a range of neurological symptoms including numbness, tingling, vision impairment, cognitive impairment, and bladder and bowel dysfunction (Tafti et al., 2024)

Choline : Choline is an essential amino acid that is used throughout the body to build cell membranes, maintain healthy muscle and liver function, and produce acetylcholine, a neurotransmitter that regulates mood and is involved in forming memories and controlling muscle contractions