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When considering the aspect of compensating the abnormal melatonin secretion rather than the advancing effect of melatonin rhythm, it might be reasonable to opt for high doses of melatonin

E-Posters - RISK FACTORS - PRIMARY AND SECONDAR PREVENTION 05.00 - RISK FACTORS AND PREVENTION (PRIMARY AND SECONDARY) - 05.03 - EPIDEMIOLOGY & RISK FACTORS P2547 - ESOC25-1854 HISTORY OF PREGNANCY COMPLICATIONS AND THE RISK OF ISCHEMIC STROKE IN YOUNG WOMEN Esme Verburgt 1 , Nina Hilkens 1 , Jamie Verhoeven 1 , Mijntje Schellekens 1 , Merel Ekker 1 , Esther Boot 1,2 , Paulus J.A.M

This is why chronic stimulation of the HPA axis is pro-inflammatory, whereas its acute stimulation is anti-inflammatory (277, 278)

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