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Since mitochondria are one of the crucial organelles involved in the manifestation of radiation-induced apoptosis, Stoyanovsky and coworkers anticipated that mitochondrial targeting of ebselen may further improve its radioprotective activity by detoxifying the mitochondrial overproduction of hydroperoxide (H 2 O 2 ) and the accumulation of lipid hydroperoxides

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Blood 106:785a, 2005

Both parameters separated patients with LSM above 6.5 kPa and signs of portal hypertension from those with LSM below 6.5 kPa with an AUROC of 0.87 (TSP2) and 0.85 (IGFBP7)