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To study the role of the mAChR on glycemic levels, 5 min before glucose infusion, an intraperitoneal injection of acetylcholine (ACh), a cholinergic physiological agonist (ACh, 27 nmol/l/kg bw), or atropine, a cholinergic non-selective antagonist (Atr

Participants in the oral semaglutide arm underwent a dose-escalation schedule (3 mg daily for 4 weeks, followed by 7 mg daily for 4 weeks, then 14 mg daily for the remainder of the trial) to minimize gastrointestinal side effects