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Mitotic catastrophe, arising from mitotic errors, capitalizes on the unbridled proliferation of cancer cells, offering an alternative route to cell death distinct from classical apoptosis and providing insights into drug resistance [96, 97]

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278 In addition to its local effects, TNF- released from the pancreas contributes to inflammation in distant organs such as the lungs, promoting events such as endothelial activation, leukocyte recruitment, and capillary leakage