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All patients were initially evaluated and diagnosed with BMS according to the diagnostic criteria defined by the International Classification of Headache Disorders, 3rd edition (ICHD-III) 22

These widespread effects include upregulation of genes involved in matrix synthesis, cell adhesion, growth factor signaling, and tissue remodeling, alongside downregulation of genes associated with inflammation, oxidative stress, and cellular senescence

In a Phase 2 dose-finding clinical trial, cagrilintide was administered at 0.3 to 4.5 mg once weekly via subcutaneous injection over approximately 26 weeks

By inhibiting the reuptake of these neurotransmitters, they are more present around cells