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These parallel hits drive inflammation, hepatocellular ballooning, and subsequent fibrosis, forming the critical juncture that determines the risk of progression to cirrhosis and HCC

Given the fact that 11 out of 14 study subjects were 60 years old or older and one subject was on insulin treatment, HOMA-IR might have underestimated the reduction in insulin resistance that occurred at the end of 4th week during 4-week intermittent fasting

When growth hormone is delivered in pulses, downstream gene expression reflects regulated signaling dynamics rather than sustained receptor saturation

It requires caloric deficit, adequate dietary protein (minimum 0.8g per pound of body weight), and metabolic demand from resistance training or structured cardio