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Ruiz said he was not surprised that second-line noninsulin antidiabetic medications like GLP-1 receptor agonists are safe for use during pregnancy because they are very similar to medications used in the past to treat pregestational diabetes, such as metformin and If youre a type 2 diabetic and on one of those GLP-1 medications and its controlling your blood sugar, thats actually what we want, he explained