Stem cell-based therapy should not be viewed as a replacement for established supportive care such as behavioral therapy, speech therapy, occupational therapy, educational interventions, and developmental follow-up
In line with this hypothesis, recent studies suggest that the BDNF/pro-BDNF ratio is altered in neurological diseases, leading to an imbalance in serum levels of pro- and mBDNF, which may play an important role as biomarkers in these pathologies 8,25,26,27
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Their action is fast, short-acting, and because they are upstream signaling agents, they tend to be more broadly focus on influencing multiple chemical pathways