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In our carnitine-bound structure, we identify a Na + binding site sandwiched between TM1 and TM4 of the N-terminal bundle, which is further housed within an aqueous cavity that extends upward within the N-terminal domain (Figs

Disrupting the phosphatidylinositol (PI) 3-kinase VPS34 ( CPAR2_206880 ) also induced hypersensitivity to oxidative and cell wall stresses, copper and cadmium, and azoles (Fig

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Nivoit P, Wiernsperger N, Moulin P, Lagarde M, Renaudin C