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Studies show REV-ERB and REV-ERB nuclear receptors control circadian rhythm and metabolic genes

What they found: Dose-dependent stimulation of type II collagen (up to 2.5 baseline at 100 nM) Stimulation of aggrecan (up to 1.8 baseline) Inhibition of MMP-13 by ~40 % Partial protection against IL-1-induced matrix degradation Why it matters: It opened a completely new research area for AOD-9604 beyond lipolysis

Reduction of total fluid volume occurs through the inhibition of sodium reabsorption in the distal tubules, which causes increased excretion of sodium, water, potassium, and hydrogen