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A melanocortin peptide, PT 141, activates melanocortin receptors in the brain

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Another study suggested that combined QE and simvastatin attenuated hepatic fibrosis in rats by lowering serum levels of GOT, GPT, ALP, decreasing hepatic mRNA levels of sphingosine kinases type 1 (SphK1) and NLRP3 and elevating total antioxidant capacity, glutathione and Nrf2 expression levels, suggesting that targeting the SphK1/NLRP3 pathway could be a prospective therapeutic strategy against liver fibrosis (Salama et al., 2024)

10.1172/JCI118791