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Gooseberry anthocyanins protect mice hepatic fibrosis by inhibiting TGF/Smad pathway

10.1007/s12975-014-0340-3 12 GaoX.ZhangY.BurwinkelB.XuanY.HolleczekB.BrennerH.et al (2019)

When I attended, I was greeted by the receptionist and asked to wait in the very lovely waiting room

Crucially, this study shifted the scientific paradigm from a simple model of "glutathione depletion" to a model of an "overwhelmed compensatory mechanism." The discovery that circulating immune cells in these patients actually have elevated glutathione levelswhile simultaneously suffering from a severe depletion of other protective enzymes like SOD2revealed that the cells are desperately, and unsuccessfully, trying to fight off a catastrophic level of oxidative damage