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In mice, the dual agonist tirzepatide suppressed total caloric intake, while promoting intake of chow over high fat/sucrose diet (HFD)

According to the IFEBP survey, the top 10 factors when considering covering GLP-1 drugs for obesity are: Obesity as a risk factor for chronic diseases and associated costs Drug shortages Impact/effectiveness of cost-control mechanisms Existing coverage through government programs Long-term costs Patient and prescriber demand Broker/consultant/ PBM recommendations Lack of long-term use clinical studies of GLP-1 drugs Side effects Similar drugs in research and development The cost of these drugs can range from a minimum of $200 to $300 a month, and this cost would stretch over a long period of time, as GLP-1 drugs for weight loss require prolonged use, Bajaj said

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Overall, only phentermine and its derivatives as well as orlistat were available and used for weight management