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Elderly patients should call 999 immediately if they experience difficulty breathing, throat tightness, facial swelling, or widespread rash after B12 administration, as these may indicate a rare but serious allergic reaction requiring emergency treatment

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The tendency for increased t 1/2 with increasing renal impairment was not considered clinically relevant, as exposure was similar between groups, and results supported once-weekly SC administration of cagrilintide

The research peptide is a synthetic version of this naturally occurring fragment