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Description

The endocrine hypothesis of ageing proposes that hormones govern ageing, with the evolutionary conserved insulin/IGF-1 signalling pathway playing a key role in hormonal ageing regulation (Tullet et al., 2014)

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The "TwoSampleMR" R package in the R software was utilized to extract IVs associated with exposure by setting parameters (P = 1e-5, clump = True, r2 = 0.001, kb = 10000) [23, 29]