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Additionally, many patients initiating tirzepatide have pre-existing conditions such as obesity and type 2 diabetes, which are independently associated with higher rates of osteoarthritis and joint pain

It followed 307 adults who were living with obesity or were overweight and dealing with at least one related health condition, like high blood pressure, prediabetes, or high cholesterol

These effects were consistent across participants aged 65 and 60 years with obesity or overweight and at least one weight-related comorbidity experienced a 510% reduction in baseline body weight following 24 weeks of liraglutide treatment, although body composition was not assessed in this study [44]

Neurology 1989;39:291-302