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This product contains 200 mg of caffeine per serving and is not recommended for children, pregnant, or breastfeeding women

Paraxanthine has been shown to increase BDNF levels to a greater extend compared to caffeine in a preclinical study [10], which translated in increased cognitive performance in a clinical study investigating the ability to shift between tasks [34]

Furthermore these receptors have RAMPS or receptor activity modifying proteins, RAMP1 & AMY1 act on fat storage/adiposity, RAMP3 & AMY3 seem to act on eating preference and glucose control

While this is indicative of how obesity and its treatment were seen at the time, I believe the sentiment is shifting as our knowledge of obesity improves, and our understanding that obesity is a progressive and relapsing disease worthy of high quality treatments and care grows