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However, this review also noted that the quality of the studies was not very high, so more studies are needed before its possible to make any firm recommendations

It should be noted that the prototype SGLT1 and SGLT2 blocker, phorizin, did not achieve suitability for human use due to considerable problems (i.e., diarrhea, dehydration, and malabsorption due to small intestine SGLT1 inhibition) [42,43,44]

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Tirzepatide, a dual GIP/GLP-1 agonist, has shown even greater weight loss than semaglutide in clinical trials