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Metformin is the first-line treatment for type 2 diabetes and works primarily by reducing hepatic glucose production and improving insulin sensitivity

Vierucci A, De Martino M, Graziani E, Rossi ME, London WT, Blumberg BS

Group mean metabolite concentrations were significantly lower in the patients than in the controls for both glutathione and glutamine in the ACC, and significantly lower for all three metabolites in the ACC in the subset of patients with residual schizophrenia