what are the side effects of glp-1 for weight loss Drugs? Common, uncommon, and rare side

L-carnitine and peripheral artery diseases Several studies have shown the effectiveness of carnitine as a dietary supplement in the treatment of cardiac ischemia (restriction of blood flow to the heart) and peripheral artery disease (the main symptom is poor circulation in the legs, known as intermittent claudication)

Highest dose, obesity trial obesity-plus-diabetes trial (treatment-policy estimand): Semaglutide: 14.9% (STEP 1) 9.6% (STEP 2), a 5.3 point gap Tirzepatide: 20.9% (SURMOUNT-1) 14.7% (SURMOUNT-2), a 6.2 point gap Retatrutide: 25.0% (TRIUMPH-1) 20.8% (TRIUMPH-2 only efficacy-estimand currently reported so true gap is larger) It's still unclear the reason why we observe less weight loss in those with type 2 diabetes

This effect is dose-dependent, meaning higher doses increase the likelihood of digestive slowdown

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