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In the intention-to-treat (ITT) analysis, cohort members were followed from index date until first registration of suicide or suicide attempts, emigration, death, switching to the other study drug or end of follow-up (31 December 2022)

Through multiple pathways, amino acid metabolism determines the direction of macrophage polarization in MS, and together these mechanisms highlight the dual role of amino acid metabolism in MS pathogenesis and as a therapeutic target

The agency said these issues showed bigger problems with Novo Nordisks pharmacovigilance system

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