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Therefore, future prospective studies with standardized protocols for C-peptide measurement are warranted to further elucidate the pathophysiology of SGLT2 inhibitor-associated DKA

ELIXA trial included patients with recent cardiovascular event (patients with acute coronary syndrome 180 days before randomization), and although there was no benefit in MACE reduction in lixisenatide treated patients compared to placebo, results revealed cardiovascular safety of lixisenatide in this specific high risk population (38, 40)

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