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Protein complex prediction with AlphaFold-Multimer

Diabetologia (2005) 48:6125.10.1007/s00125-005-1705-7 94 DeaconCFPridalLKlarskovLOlesenMHolstJJ

This mechanism amplifies existing HGF signaling rather than bypassing it: HGF Potentiation: Dihexa binds to HGF and stabilizes its active conformation, increasing c-Met receptor activation at physiologically relevant HGF concentrations Synaptogenesis: In vitro studies reported that Dihexa promoted new synapse formation at picomolar concentrations orders of magnitude more potent than BDNF in this specific assay Dendritic Spine Formation: Preclinical data suggested increases in dendritic spine density in hippocampal neurons, a structural correlate of learning and memory Oral Bioavailability: Unlike most peptides, Dihexa's small size and peptidomimetic structure may allow oral absorption and blood-brain barrier penetration Cerebrolysin: Multi-Neurotrophic Factor Cocktail Cerebrolysin is a standardized mixture of low-molecular-weight neuropeptides and free amino acids obtained by enzymatic breakdown of porcine brain tissue

Week 12: -0.62.1, -0.71.5, 0.12.4 mmol/L, for placebo, tesamorelin 1 mg, and tesamorelin 2 mg, respectively, p = 0.44