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Consistent with the cryo-EM structure, the MD analysis revealed the GLP-1 N-terminus forms extensive interactions with TMs 1, 2, 3, 5, 6, 7 and ECLs 1-3 (Figure 6, Supplemental Figure 11)

It works by neutralizing free radicals and reducing oxidative stress, which can exacerbate inflammatory skin issues like acne, rosacea, and eczema

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Modified DPP-4 can not only mask the enzymatic hydrolysis site of DPP-4 but also bind closely with albumin to reduce renal excretion and prolong the half-life