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In the UK, D-allulose is classified as a novel food and requires authorisation from the Food Standards Agency (FSA) before widespread commercial use, with specific conditions of use that must be followed

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This conformation of KEAP1-NRF2 complex allows an adequate Lysine (Lys) rich -helix orientation in the Neh2 domain for KEAP1-dependent polyubiquitination [157]

Resveratrol induces TFEB expression and enhances autophagy, improving insulin sensitivity and reducing hepatic steatosis in animal models, although clinical benefits in humans have thus far been modest