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143,144 The mutated IDH1 and IDH2 proteins are endowed with a novel ability to catalyze the reduction of -KG to generate a rare metabolite, 2-hydroxyglutarate (2-HG), while consuming NADPH

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Multi-peptide protocols require thorough medical evaluation and ongoing monitoring

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Furthermore, chronic GIP-receptor agonism can lead to desensitization and eventual loss of GIP receptor activity, which then mimics antagonism

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