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In a randomised, placebo-controlled double blinded phase 1 study of ascending single doses in healthy overweight humans, cotadutide was shown to be safe and, in common with the GLP-1 analogues, to be associated with dose-dependent gastrointestinal adverse events especially nausea and vomiting

Switching between GLP-1 medications is common and can be done for several reasons: intolerable side effects on the current medication, insufficient response after an adequate trial period, changes in availability, or changes in insurance coverage

Chytra V Anand, Founder Kosmoderma

It is one of the so-called "corrective factors", and its main property is to promote wound healing and damage within the soft tissues