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Symptoms include stiffness, soreness, and a dull, aching pain, either widespread or localized

[124] In 2009 Imai proposed the "NAD World" hypothesis that key regulators of aging and longevity in mammals are sirtuin 1 and the primary NAD + synthesizing enzyme nicotinamide phosphoribosyltransferase (NAMPT)

Conclusion The past two decades have witnessed a paradigm shift in the study of MuSC aging, fueled by continuous advances in transcriptomic technologies and the analytical frameworks built around them