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Moreover, there are several paradigmatic conditions such as Down syndrome, phenylketonuria, and various lipidoses (Scriver et al., 1989) where the metabolic abnormalities are expressed in both neural and peripheral tissues, but the functional consequences are most profound in the central nervous system (CNS)

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GLP-1 RA medications like semaglutide, liraglutide, Tirzepatide, and dulaglutide stimulate GLP-1 receptors, improving insulin sensitivity, regulating blood sugar, and reducing appetite