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The pharmacokinetics of LY3437943 (retatrutide) support once-weekly administration due to an elimination half-life of approximately 6 days. Jastreboff AM et al., Nature Medicine, 2023 This extended half-life is made possible by attaching a fatty acid chain to the peptide, allowing it to bind to albumin a common protein in your blood that acts like a slow-release carrier

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[Google Scholar] 61.Fei S, Feng X, Luo J, Guo L, Pan Q

Patients often receive prior authorization approval but typically need to have tried other strategies, like behavioral and dietary changes, for at least three months before coverage is approved. RELATED: Can I take Ozempic if Im not diabetic