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Since PF-06882961 does not activate the rodent GLP-1R, the therapeutic effects of PF-06882961 on insulin and glucose were examined in an IV glucose tolerance test (IVGTT) in cynomolgus monkeys

The concentrations of glucose and acetic acid were monitored by HPLC (LC-10AT, Shimadzu, Japan) using an Amines HPX-87H column (Bio-Rad, USA) and a refractive index detector (RID-10A, Shimadzu, Japan)

Segundo Miranda, passar pela aprovao das agncias reguladoras no significa que no existam efeitos adversos que devem ser monitorados e acompanhados, mas que assegura que o medicamento foi avaliado para a segurana em seres humanos

Encourages fat breakdown during fasting