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doi: 10.1038/s42255-025-01342-6 Majellaro M, Bondar A

found that the DNA repair and REDOX functions of APE1 were also essential for maintaining mitochondrial integrity [23]

New or worsening neurological symptoms (such as progressive numbness, ataxia, or significant cognitive changes) warrant urgent assessment and should not be ignored, as delayed treatment may result in permanent nerve damage

The study received funding from Wellcome, Medical Research Council, European Union Horizon 2020 Programme, the National Institutes of Health (grants U01-DK105535, U01-DK085545 and UM-1DK126185), the National Institute for Health Research Oxford Biomedical Research Centre, the Canadian Institutes of Health Research, the Novo Nordisk Foundation, Boehringer Ingelheim and Diabetes Australia.