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This data underscores the significance of PSPH genetic aberrations leading to ser/gly synthesis metabolic rewiring to support and sustain the aggressive and immunosuppressive phenotype of GBM tumors

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The mechanistic rationale is strong, the safety profile is established, and the observation that psoriatic arthritis patients have lower thymosin alpha-1 levels is suggestive

As a metabolic neuroscientist specializing in the neuroendocrine control of energy balance and the metabolic dysregulation that accompanies obesity, Geisler was interested in the role of glial cells specifically tanycytes and astrocytes