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A meta-analysis of 18 studies encompassing 493 ASD patients and 404 neurotypical individuals revealed distinct gut microbiota patterns in ASD, characterized by elevated levels of Bacteroides , Parabacteroides , Clostridium , Faecalibacterium , and Phascolarctobacterium and reduced Coprococcus and Bifidobacterium abundances [304]

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Moreover, the ER stress-induced activation of protein kinase R upregulates p62 that, as previously mentioned, is able to compete with Keap1 for Nrf2 binding, to stabilise Nrf2 [147]

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