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3 Another study noted that GLP-1 medications may be more effective when started 74+ months after surgery, possibly because the natural elevation in GLP-1 from surgery begins to wane over time

Semaglutide, also via GLP-1R/cAMP signaling, promoted mitochondrial biogenesis by increasing levels of PGC-1 and SIRT1 and antioxidant activity through the expression of the NRF2-regulated antioxidant genes [183]

In randomized clinical trials, about 17% of patients dropped out due to side effects of semaglutide compared to 8% in the placebo group, most often due to GI problems