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The dose may need to be changed based on your health goals and how well you can take the medicine

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Adverse Effects * Headache * Nausea * Abdominal pain * Diarrhea or constipation * Flatulence Long-term use * Vitamin B12 deficiency * Hypomagnesemia * Increased fracture risk * Increased risk of enteric infections (e.g., Clostridioides difficile) * Possible increased risk of community-acquired pneumonia Contraindications * Hypersensitivity to omeprazole or other PPIs * Use with drugs where interaction is contraindicated (e.g., certain formulations of rilpivirine) Drug Interactions * May reduce activation of Clopidogrel (clinical significance varies