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The propensity score was constructed from age at the index date (continuous), sex, race, region, number of RMS relapses in the preindex period (0, 1, 2+), prior DMT in the preindex period, RMS disability in the preindex period, Deyo-Charlson comorbidity index (DCCI) in the preindex period (continuous), and Psychiatric Diagnosis Group index in the preindex period (continuous)

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Key Takeaways Gradual dose escalation over 20 weeks minimizes gastrointestinal side effects while building therapeutic efficacy Standard monotherapy reaches a maximum maintenance dose of 4.5 mg weekly after systematic increases Combination protocols (CagriSema) pair cagrilintide with semaglutide for enhanced weight management outcomes Clinical trial data demonstrates approximately 10.8% body weight reduction with monotherapy at 32 weeks Proper injection technique and site rotation are essential for optimal absorption and safety Understanding Cagrilintide: What Health Professionals Need to Know Cagrilintide is a long-acting amylin analogue currently being developed by Novo Nordisk for obesity and type 2 diabetes management

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