* Correspondence: Ion-Bogdan Dumitrescu, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
In addition to erythropoiesis, HIF binding across the genome turns on many target genes transcriptionally and helps with many physiological and developmental processes, such as blood vessel growth, energy metabolism, iron homeostasis, cell proliferation, differentiation, and iron homeostasis
Cells were cultured in Dulbeccos Modified Eagles medium (Welgene LM001-05) supplemented with 10% fetal bovine serum (Gibco 16000-044), and 1% penicillin/streptomycin (Gibco 15140-122)
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