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Leveraging nuclear factor erythroid 2-related factor 2 (Nrf2) pathway Nrf2 is a ubiquitously expressed transcription factor that regulates the expression of around 20 antioxidant genes to provide protection against oxidative stress

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Importantly, these HDTs significantly reduce microglial activation in Mycobacterium tuberculosis -infected human brain organoids and attenuate proinflammatory cytokines, particularly IFN within CD4+ T-cells in patient-derived PBMCs