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Evidence for atrial inflammation in the context of ischemic myocardial infarction has been detected in both animals and humans, generally associated with infiltration of immune cells, including macrophages, lymphocytes and neutrophils, and upregulation of cytokine mRNA transcripts, including Il1b and Tnf [61,62]

A decade on from the first immunotherapy approval, how much do we know about these cryptic harms and how do we balance their risk with the undeniable benefits of immunotherapy