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In controlled trials in heart failure patients, the incidence of hypotension in valsartan-treated patients was 5.5% compared to 1.8% in placebo-treated patients

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An azide-bearing ncAA, NEAK, was site-specifically incorporated into IFN-2b at distinct locations, allowing orthogonal and stoichiometric conjugation to PEG via a copper-free cycloaddition reaction